Metalloenzymes catalyze a broad range of biological transformations important for cofactor biosynthesis, antibiotic production, and primary metabolism. Visualizing their catalytic processes in real-time, however, is technically challenging and our understanding of this vast mechanistic landscape remains limited.
Our lab focuses on the development and application of time-resolved physical methods to elucidate the mechanisms of metal-containing enzymes important for human health and medicine. In particular, we interrogate the concerted modulation of electronic properties and structural dynamics which facilitate metallocofactor function using carefully tailored spectroscopic and crystallographic experiments. Working at the interface of physics, chemistry and biology, we welcome members from all scientific backgrounds and experiences.